ELOQUENT-2 updates represent the longest median FU of an immuno-oncology agent in MM

Clinical Pearls Podcasts published on July 10, 2017
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Sagar Lonial, MD
Chair and Professor
Department of Hematology and Medical Oncology
Chief Medical Officer
Winship Cancer Institute
Emory University School of Medicine
Atlanta, Georgia
ELOQUENT-2 updates represent the longest median FU of an immuno-oncology agent in MM

Hello, I am Dr. Sagar Lonial from the Winship Cancer Institute at Emory University in Atlanta, Georgia. I am here at ASCO 2017 talking about the ELOQUENT-2 update that I presented at this meeting. ELOQUENT-2 was a randomized phase 3 trial treating patients with either lenalidomide-dexamethasone with or without elotuzumab, in a one to three prior lines of therapy study. It was published 2 years ago in the New England Journal of Medicine, demonstrating a significant improvement in overall response rate as well as progression-free survival. What we show at this meeting is a 4 year update on that trial where we are demonstrating, I think quite nicely, that the benefit in terms of progression-free survival continues to hold up at about 30% improvement in PFS. There is no increase or change in the adverse events, and most importantly, we are now showing survival curves with a hazard ratio of about 0.63, although there is no P-value available on that hazard ratio at this time. I think in summary what this suggests is that elotuzumab plus lenalidomide and dexamethasone in an early relapsed patient population continues to demonstrate benefit in 4-year follow-up, and that there is not clear statistical improvement but hints at improvement in overall survival, without a significant increase in adverse events. Thank you for listening.

Last modified: July 10, 2017