Proteasome Inhibitor plus IMiD or HDAC Inhibitor Regimens in R/R Myeloma Management
Release Date: July 13, 2016
Expiration Date: July 13, 2017
Expected time to complete this activity as designed: 30 minutes
There are no fees for participating in or receiving credit for this online activity.
The treatment landscape for relapsed/refractory multiple myeloma (MM) is evolving with the availability of new therapies, including the third-generation immunomodulatory drug pomalidomide, and the histone deacetylase inhibitor panobinostat. These new therapies present a challenge to community oncologists who must determine how to incorporate these drugs into clinical practice. Dr. Antonio Palumbo, Associate Professor of Clinical Hematology and Director of the Myeloma Program at the University of Torino, provides an overview of the most recent data supporting the use of pomalidomide and panobinostat in proteasome inhibitor-containing regimens, and shares clinical expertise in managing patients with relapsed/refractory MM who receive these therapies.
This activity is designed for physicians, pharmacists, physician assistants, and other health care professionals who have an interest in enhancing their clinical skills in multiple myeloma.
Upon completion of this educational activity, participants should be able to:
- Recall dose schedules for triple-agent regimens comprising either of the currently available proteasome inhibitors plus third-generation IMiD plus dexamethasone, or the approved combination of proteasome inhibitor plus HDAC inhibitor plus dexamethasone
- Compare and contrast which patients may benefit from PAN-BTZ-Dex, Car-Pom-Dex or POM-BORT-LoDEX regimens in the relapsed/refractory disease setting
- Identify efficacy and safety signatures for discussed regimens, and mitigation strategies which may reduce the frequency or severity of their occurrence
Integrating Proteasome Inhibitor Plus Either Third-Generation IMiD or Histone Deacetylase Inhibitor-Based Regimens into Relapsed/Refractory Multiple Myeloma Management – Antonio Palumbo, MD
Instructions for Participation and Credit
This activity is eligible for credit through July 13, 2017. After this date, this activity will expire and no further credit will be awarded.
- Read the target audience, learning objectives, and faculty disclosures.
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- Complete the educational content as designed.
- Complete the post-test. To receive a certificate, you must receive a passing score of 70%.
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- Certificates for CME credit may be printed immediately after successfully completing the post-test and activity evaluation. Pharmacist credit will be uploaded to CPE Monitor 4 weeks following receipt of a completed, qualified form.
Antonio Palumbo, MD
Associate Professor of Clinical Hematology
Director, Myeloma Program
Department of Oncology
University of Torino
Dr. Antonio Palumbo received his medical degree from the University of Torino, Italy, where he served his residency in internal medicine and held a fellowship in hematology/oncology. He is an Associate Professor of Clinical Hematology, and Director of the Myeloma Program, Department of Oncology at University of Torino. He is also a visiting physician at University of Texas MD Anderson Cancer Center in Houston.
In addition to membership in numerous professional organizations, including the Italian Society of Hematology (SIE), Italian Society of Experimental Hematology (SIES), European Society of Medical Oncology (ESMO), European Society of Hematology (EHA), American Society of Hematology (ASH) and the American Society of Clinical Oncology (ASCO), Dr. Palumbo is on the Board of Directors of the International Myeloma Society. He has authored more than 400 publications in peer-reviewed journals as well numerous abstracts and several textbook chapters. Dr. Palumbo specializes in malignant hematology and medical oncology and has clinical and research interest in plasma cell dyscrasia, his current research focuses on the pathogenesis and treatment of multiple myeloma.
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Designation Statement: MediCom Worldwide, Inc. designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
MediCom Worldwide, Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This activity is acceptable for 0.50 contact hours of Continuing Education Credit. Universal Activity Number: 827-0000-16-090-H01-P. Knowledge-based CPE activity.
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As an organization accredited by the Accreditation Council for Continuing Medical Education (ACCME), Accreditation Council for Pharmacy Education (ACPE) and California State Board of Registered Nursing, MediCom Worldwide, Inc. requires everyone who is a position to control the content of an educational activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines “relevant financial relationships” as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest. Accordingly, the following disclosures were made.
Dr. Antonio Palumbo has received honoraria related to speakers’ bureau activities from Bristol-Myers Squibb Company. He has received grant support related to research activities as well as honoraria as a consultant from Amgen Inc., Bristol-Myers Squibb, Celgene Corporation, Genmab A/S, Janssen-Cilag Ltd., Merck & Co., Inc., Novartis AG, sanofi-aventis U.S. LLC, and Takeda Oncology.
Planning Committee Disclosures
The individuals listed below from MediCom Worldwide, Inc. reported the following for this activity: Joan Meyer, RN, MHA, Executive Director, and Patrick Brooks, PharmD, Medical Director, Oncology have no relevant financial relationships.
Peer Reviewer Disclosure
In accordance with MediCom Worldwide, Inc. policy, all content is reviewed by external independent peer reviewers for balance, objectivity and commercial bias. The peer reviewers have no relevant financial relationships to disclose.
Off-Label Disclosures/Investigational Disclosures
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, attendees/participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.
Dr. Palumbo has indicated that he does intend to discuss off-label uses of drugs, mechanical devices, biologics or diagnostics approved by the US Food and Drug Administration (FDA) for use in the US.
Dr. Palumbo has indicated that he does intend to discuss investigational drugs, mechanical devices, biologics or diagnostics not approved by the FDA for use in the US.
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This activity is supported by an educational grant from Amgen Inc.
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